Inositol is a sugar alcohol, formerly known as vitamin B8, although it is not actually a vitamin. The body can synthesize it from glucose, and its two most important forms are myo-inositol and D-chiro-inositol. This compound is often mentioned in the context of hormones, metabolism, and PCOS.
Inositol properties
Simply put, inositol is involved in processes related to insulin action and may support a better body response to this hormone. This is important because insulin is responsible for m.in. responsible for regulating blood glucose levels. Myo-inositol is more involved in the transport of glucose into cells, while D-chiro-inositol is more involved in its further utilization and storage. In practice, the properties of inositol are often utilized where insulin sensitivity issues arise. Questions about inositol's function and function are often raised in the context of PCOS, or polycystic ovary syndrome.
Inositol and PCOS
Some studies suggest that inositol may have a beneficial effect on blood sugar levels and some hormonal parameters. m.in. improved insulin response, reduced some markers associated with androgen excess, and beneficially affected certain elements of the menstrual cycle. In healthy women, the plasma myo-inositol-D chiro-inositol ratio is approximately 40:1. In women with PCOS, this balance is disturbed. Insufficient myo-inositol in ovarian follicles can disrupt processes important for proper follicular maturation. In turn, excess D chiro-inositol in the ovary may promote increased androgen production. However, the latest large review emphasizes that, despite promising results, the evidence remains limited.
Inositol and weight loss
The issue of inositol and weight loss should be approached sensibly. Inositol may indirectly support weight loss in some individuals, especially those with metabolic disorders and insulin resistance. A meta-analysis of clinical trials demonstrated a small but statistically significant effect of inositol supplementation on reducing BMI.
Inositol and the thyroid
This association is emerging with increasing frequency, particularly in Hashimoto's thyroiditis and subclinical hypothyroidism. Currently, the most data concern the combination of myo-inositol and selenium. Some recent reviews suggest that this combination may affect TSH and certain thyroid antibodies, but it still does not replace standard diagnostics or therapy.
Which inositol should I choose?
If you're wondering which inositol to choose, first check the form of the supplement. Myo-inositol is the most common. D-chiro inositol is also found in supplements, although this form is less common than myo-inositol. Products targeted at women with PCOS often feature a 40:1 ratio, as this is considered the most physiological. When choosing, it's worth considering not only the marketing but also the specific ingredients, dosage, and label clarity.
Inositol dosage
The dosage of inositol depends primarily on the purpose of supplementation, the form of the preparation and the individual health situation.
Inositol side effects
As for what inositol has Regarding side effects, available data indicate that this compound is generally well tolerated. The most frequently reported side effects are mild gastrointestinal complaints, and the safety review noted that more pronounced symptoms occurred primarily at very high doses.
Where else can you find it?
It's worth remembering that this compound is found in food. Good sources include m.in. Fruits, beans, peas, cereals, nuts, and seeds. This is important information for people who want to improve their diet before reaching for tablets containing myo-inositol.
Sources:
Holistic Health, No. 2/2006
https://pmc.ncbi.nlm.nih.gov/articles/PMC8896029/
https://pubmed.ncbi.nlm.nih.gov/25010620/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9159559/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11624528/
